Title : GEF-H1/RhoA signalling pathway mediates lipopolysaccharide-induced intercellular adhesion molecular-1 expression in endothelial cells via activation of p38 and NF-κB.

Pub. Date : 2012 Mar

PMID : 22226621






2 Functional Relationships(s)
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1 Furthermore, pretreatment with Y-27632, an inhibitor of ROCK, significantly reduced LPS-induced p38, ERK1/2 and p65 phosphorylation, indicating that ROCK acts as an upstream effector of p38 and ERK1/2 to promote LPS-induced NF-kappaB transactivation and ICAM-1 expression. Y 27632 mitogen-activated protein kinase 1 Homo sapiens
2 Furthermore, pretreatment with Y-27632, an inhibitor of ROCK, significantly reduced LPS-induced p38, ERK1/2 and p65 phosphorylation, indicating that ROCK acts as an upstream effector of p38 and ERK1/2 to promote LPS-induced NF-kappaB transactivation and ICAM-1 expression. Y 27632 mitogen-activated protein kinase 1 Homo sapiens