PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22226621-7 2012 Furthermore, pretreatment with Y-27632, an inhibitor of ROCK, significantly reduced LPS-induced p38, ERK1/2 and p65 phosphorylation, indicating that ROCK acts as an upstream effector of p38 and ERK1/2 to promote LPS-induced NF-kappaB transactivation and ICAM-1 expression. Y 27632 31-38 mitogen-activated protein kinase 1 Homo sapiens 96-99 22226621-7 2012 Furthermore, pretreatment with Y-27632, an inhibitor of ROCK, significantly reduced LPS-induced p38, ERK1/2 and p65 phosphorylation, indicating that ROCK acts as an upstream effector of p38 and ERK1/2 to promote LPS-induced NF-kappaB transactivation and ICAM-1 expression. Y 27632 31-38 mitogen-activated protein kinase 1 Homo sapiens 186-189