PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22129452-1 2011 BACKGROUND: Synthetic activators of peroxisome proliferator-activated receptors (PPARs) stimulate cholesterol removal from macrophages through PPAR-dependent up-regulation of liver x receptor alpha (LXRalpha) and subsequent induction of cholesterol exporters such as ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type 1 (SR-BI). Cholesterol 98-109 peroxisome proliferator activated receptor alpha Mus musculus 81-85 22129452-1 2011 BACKGROUND: Synthetic activators of peroxisome proliferator-activated receptors (PPARs) stimulate cholesterol removal from macrophages through PPAR-dependent up-regulation of liver x receptor alpha (LXRalpha) and subsequent induction of cholesterol exporters such as ATP-binding cassette transporter A1 (ABCA1) and scavenger receptor class B type 1 (SR-BI). Cholesterol 237-248 peroxisome proliferator activated receptor alpha Mus musculus 81-85 22129452-6 2011 Pre-treatment of cells with a selective PPARalpha or PPARgamma antagonist completely abolished the effects of 13-HODE on cholesterol efflux and protein levels of genes investigated. Cholesterol 121-132 peroxisome proliferator activated receptor alpha Mus musculus 40-49 22129452-8 2011 CONCLUSION: 13-HODE induces cholesterol efflux from macrophages via the PPAR-LXRalpha-ABCA1/SR-BI-pathway. Cholesterol 28-39 peroxisome proliferator activated receptor alpha Mus musculus 72-76