| Protein Name | peroxisome proliferator activated receptor alpha |
|---|---|
| Organism | Mus musculus |
| Gene ID | 19013 |
| Gene Symbol | Ppara |
| UniProt | P23204 (PPARA_MOUSE), Q542P9 (Q542P9_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
1052
Total Number of Articles : 2133 |
Description |
peroxisome proliferator activated receptor alpha |
| Gene Summary |
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; lipid binding activity; and nuclear receptor activity. Involved in several processes, including negative regulation of appetite; peroxisome proliferator activated receptor signaling pathway; and regulation of gene expression. Acts upstream of or within several processes, including enamel mineralization; positive regulation of biosynthetic process; and protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; early conceptus; gut; hemolymphoid system gland; and skeletal muscle. Used to study diabetes mellitus and schizophrenia. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Jun 2025] |
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