Pub. Date : 2012 Jan 15
PMID : 22128299
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | RESULTS: Upon CD40 stimulation patient-specific variations in ABT-737 sensitivity correlated with differences in levels of Mcl-1 and its antagonist Noxa. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | Knockdown of Noxa, as well as Mcl-1 overexpression, corroborated the importance of the Noxa/Mcl-1 ratio in determining the response to ABT-737. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 4 | Knockdown of Noxa, as well as Mcl-1 overexpression, corroborated the importance of the Noxa/Mcl-1 ratio in determining the response to ABT-737. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 5 | Interestingly, increasing the Noxa/Mcl-1 ratio, by decreasing Mcl-1 (dasatinib and roscovitine) or increasing Noxa levels (fludarabine and bortezomib), resulted in synergy with ABT-737. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 6 | CONCLUSIONS: Thus, the Noxa/Mcl-1 balance determines sensitivity to ABT-737 in CD40-stimulated CLL cells. | 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |