PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22128299-0	2012	Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	41-44	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	17-22	
22128299-7	2012	RESULTS: Upon CD40 stimulation patient-specific variations in ABT-737 sensitivity correlated with differences in levels of Mcl-1 and its antagonist Noxa.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	62-65	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	123-128	
22128299-8	2012	Knockdown of Noxa, as well as Mcl-1 overexpression, corroborated the importance of the Noxa/Mcl-1 ratio in determining the response to ABT-737.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	135-138	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	30-35	
22128299-8	2012	Knockdown of Noxa, as well as Mcl-1 overexpression, corroborated the importance of the Noxa/Mcl-1 ratio in determining the response to ABT-737.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	135-138	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	92-97	
22128299-10	2012	Interestingly, increasing the Noxa/Mcl-1 ratio, by decreasing Mcl-1 (dasatinib and roscovitine) or increasing Noxa levels (fludarabine and bortezomib), resulted in synergy with ABT-737.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	177-180	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	35-40	
22128299-11	2012	CONCLUSIONS: Thus, the Noxa/Mcl-1 balance determines sensitivity to ABT-737 in CD40-stimulated CLL cells.	2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid	68-71	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	28-33