Pub. Date : 2012 Feb 1
PMID : 22120676
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression. | Berberine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Berberine strongly increased AMPK phosphorylation via reactive oxygen species (ROS) production. | Berberine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | Furthermore, berberine inhibited the metastatic potential of melanoma cells through a decrease in ERK activity and protein levels of cyclooxygenase-2 (COX-2) by a berberine-induced AMPK activation. | Berberine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | Furthermore, berberine inhibited the metastatic potential of melanoma cells through a decrease in ERK activity and protein levels of cyclooxygenase-2 (COX-2) by a berberine-induced AMPK activation. | Berberine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | Collectively, our results suggest that berberine-induced AMPK activation inhibits the metastatic potential of tumor cells through a reduction in the activity of the ERK signaling pathway and COX-2 protein levels. | Berberine | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |