PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22120676-0	2012	Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression.	Berberine	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	18-22	
22120676-5	2012	Berberine strongly increased AMPK phosphorylation via reactive oxygen species (ROS) production.	Berberine	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	29-33	
22120676-8	2012	Furthermore, berberine inhibited the metastatic potential of melanoma cells through a decrease in ERK activity and protein levels of cyclooxygenase-2 (COX-2) by a berberine-induced AMPK activation.	Berberine	13-22	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	181-185	
22120676-8	2012	Furthermore, berberine inhibited the metastatic potential of melanoma cells through a decrease in ERK activity and protein levels of cyclooxygenase-2 (COX-2) by a berberine-induced AMPK activation.	Berberine	163-172	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	181-185	
22120676-12	2012	Collectively, our results suggest that berberine-induced AMPK activation inhibits the metastatic potential of tumor cells through a reduction in the activity of the ERK signaling pathway and COX-2 protein levels.	Berberine	39-48	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	57-61