Title : Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2.

Pub. Date : 2011 Dec 6

PMID : 22106281






2 Functional Relationships(s)
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1 We have discovered that the enzyme phospholipase D2 (PLD2) binds directly to the small GTPase Rac2, resulting in PLD2 functioning as a guanine nucleotide exchange factor (GEF), because it switches Rac2 from the GDP-bound to the GTP-bound states. Guanosine Diphosphate Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens
2 We have discovered that the enzyme phospholipase D2 (PLD2) binds directly to the small GTPase Rac2, resulting in PLD2 functioning as a guanine nucleotide exchange factor (GEF), because it switches Rac2 from the GDP-bound to the GTP-bound states. Guanosine Diphosphate Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens