Protein Name Ras protein specific guanine nucleotide releasing factor 1
Organism Homo sapiens
Gene ID 5923
Gene Symbol


UniProt Q13972 (RGRF1_HUMAN), Q8IUU5 (Q8IUU5_HUMAN), A8K270 (A8K270_HUMAN)
Relationships Total Number of functionally related compound(s) : 93
Total Number of Articles : 148

Ras protein specific guanine nucleotide releasing factor 1

Gene Summary

The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009]

  • ras-specific guanine nucleotide-releasing factor 1
  • CDC25 like
  • Ras-specific guanine nucleotide-releasing factor, CDC25 homolog
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