Title : PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase.

Pub. Date : 2011 Dec 1

PMID : 22043008






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Loss of PTEN in macrophage leads to activation of the pleckstrin homology domain-containing guanine-nucleotide exchange factor Vav1 and subsequent activation of Rac1 GTPase, resulting in increased amounts of F-actin upon engulfment of apoptotic cells. Guanine Nucleotides vav guanine nucleotide exchange factor 1 Homo sapiens