PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22043008-6 2011 Loss of PTEN in macrophage leads to activation of the pleckstrin homology domain-containing guanine-nucleotide exchange factor Vav1 and subsequent activation of Rac1 GTPase, resulting in increased amounts of F-actin upon engulfment of apoptotic cells. Guanine Nucleotides 92-110 vav guanine nucleotide exchange factor 1 Homo sapiens 127-131