Protein Name vav guanine nucleotide exchange factor 1
Organism Homo sapiens
Gene ID 7409
Gene Symbol


UniProt P15498 (VAV_HUMAN), Q96D37 (Q96D37_HUMAN), A0A0A0MR07 (A0A0A0MR07_HUMAN), B2R8B5 (B2R8B5_HUMAN)
Relationships Total Number of functionally related compound(s) : 126
Total Number of Articles : 318

vav guanine nucleotide exchange factor 1

Gene Summary

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

  • proto-oncogene vav
  • vav 1 guanine nucleotide exchange factor
  • vav 1 oncogene
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