Title : MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML.

Pub. Date : 2012 Mar

PMID : 21904380






1 Functional Relationships(s)
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1 Previously, we showed that triptolide promotes apoptosis in acute myeloid leukemia (AML) cells via the mitochondria-mediated pathway, in part, by decreasing levels of the anti-apoptotic proteins XIAP and Mcl-1. triptolide MCL1 apoptosis regulator, BCL2 family member Homo sapiens