Title : Grape seed procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products.

Pub. Date : 2011

PMID : 21897042






2 Functional Relationships(s)
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1 The objective of this present study was to determine whether GSPB2 (grape seed procyanidin B2), which is a dimeric procyanidin and more biologically active, could inhibit AGE-induced VSMC proliferation by affecting the production of ubiquitin COOH-terminal hydrolase 1 (UCH-L1), the degradation of IkappaB-alpha and nuclear translocation of NF-kappaB in human aortic smooth muscle cells (HASMCs). procyanidin ubiquitin C-terminal hydrolase L1 Homo sapiens
2 The objective of this present study was to determine whether GSPB2 (grape seed procyanidin B2), which is a dimeric procyanidin and more biologically active, could inhibit AGE-induced VSMC proliferation by affecting the production of ubiquitin COOH-terminal hydrolase 1 (UCH-L1), the degradation of IkappaB-alpha and nuclear translocation of NF-kappaB in human aortic smooth muscle cells (HASMCs). procyanidin ubiquitin C-terminal hydrolase L1 Homo sapiens