Title : Intratumoral de novo steroid synthesis activates androgen receptor in castration-resistant prostate cancer and is upregulated by treatment with CYP17A1 inhibitors.

Pub. Date : 2011 Oct 15

PMID : 21868758






2 Functional Relationships(s)
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1 DHEA and androstenedione are synthesized by the adrenals through the sequential actions of the cytochrome P450 enzymes CYP11A1 and CYP17A1, so that CYP17A1 inhibitors such as abiraterone are effective therapies for CRPC. Androstenedione cytochrome P450 family 17 subfamily A member 1 Homo sapiens
2 DHEA and androstenedione are synthesized by the adrenals through the sequential actions of the cytochrome P450 enzymes CYP11A1 and CYP17A1, so that CYP17A1 inhibitors such as abiraterone are effective therapies for CRPC. Androstenedione cytochrome P450 family 17 subfamily A member 1 Homo sapiens