Pub. Date : 2011 Oct 30
PMID : 21742048
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we demonstrated that nNOS expression enhances the nicotine-triggered activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in nNOS-transfected PC12 (NPC12) cells. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 2 | In the present study, we demonstrated that nNOS expression enhances the nicotine-triggered activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in nNOS-transfected PC12 (NPC12) cells. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 3 | Treatment with nicotine increased the phosphorylation level of ERK1/2 in the NPC12 cells as compared with that in control PC12 cells. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 4 | The nicotine-induced ERK1/2 phosphorylation in PC12 cells was observed by their pretreatment with a NO donor. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 5 | Moreover, the enhancement of nicotine-induced ERK1/2 phosphorylation in the NPC12 cells was regulated by intracellular glutathione levels, but not by the soluble guanylate cyclase-cGMP-protein kinase G signaling. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 6 | Taken together, these findings suggest that nicotine modulates NO-dependent redox condition; the resulting calcium influx, would increase ERK1/2 phosphorylation in nNOS expressing cells. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |
| 7 | Blockade of NO pathway may be selective target to reduce ERK1/2 phosphorylation via attenuation of the nicotine responses in the CNS. | Nicotine | mitogen activated protein kinase 3 | Rattus norvegicus |