PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21742048-2	2011	In the present study, we demonstrated that nNOS expression enhances the nicotine-triggered activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in nNOS-transfected PC12 (NPC12) cells.	Nicotine	72-80	mitogen activated protein kinase 3	Rattus norvegicus	105-146	
21742048-2	2011	In the present study, we demonstrated that nNOS expression enhances the nicotine-triggered activation of extracellular signal-regulated kinase 1/2 (ERK1/2) in nNOS-transfected PC12 (NPC12) cells.	Nicotine	72-80	mitogen activated protein kinase 3	Rattus norvegicus	148-154	
21742048-3	2011	Treatment with nicotine increased the phosphorylation level of ERK1/2 in the NPC12 cells as compared with that in control PC12 cells.	Nicotine	15-23	mitogen activated protein kinase 3	Rattus norvegicus	63-69	
21742048-5	2011	The nicotine-induced ERK1/2 phosphorylation in PC12 cells was observed by their pretreatment with a NO donor.	Nicotine	4-12	mitogen activated protein kinase 3	Rattus norvegicus	21-27	
21742048-6	2011	Moreover, the enhancement of nicotine-induced ERK1/2 phosphorylation in the NPC12 cells was regulated by intracellular glutathione levels, but not by the soluble guanylate cyclase-cGMP-protein kinase G signaling.	Nicotine	29-37	mitogen activated protein kinase 3	Rattus norvegicus	46-52	
21742048-8	2011	Taken together, these findings suggest that nicotine modulates NO-dependent redox condition; the resulting calcium influx, would increase ERK1/2 phosphorylation in nNOS expressing cells.	Nicotine	44-52	mitogen activated protein kinase 3	Rattus norvegicus	138-144	
21742048-9	2011	Blockade of NO pathway may be selective target to reduce ERK1/2 phosphorylation via attenuation of the nicotine responses in the CNS.	Nicotine	103-111	mitogen activated protein kinase 3	Rattus norvegicus	57-63