Title : Calcium permeability of the nicotinic acetylcholine receptor: the single-channel calcium influx is significant.

Pub. Date : 1990 Oct

PMID : 2170596






5 Functional Relationships(s)
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1 The calcium permeability of the mouse muscle nicotinic ACh receptor (nAChR) was determined using patch-clamp techniques. Calcium cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 The calcium permeability of the mouse muscle nicotinic ACh receptor (nAChR) was determined using patch-clamp techniques. Calcium cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 In pure external calcium, the conductance of the nAChR is similar to the conductance of the NMDA receptor or the L-type Ca channel. Calcium cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
4 With pure 110-mM calcium as the external cation, the slope conductance of the nAChR channel at negative potentials is 12 pS. Calcium cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
5 The ion-permeation model predicts that calcium contributes about 2% of the total inward current through a nAChR channel in physiologic solution. Calcium cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus