Pub. Date : 2011 Sep
PMID : 21680899
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, cilostazol-activated cAMP response element (CRE)-binding protein (CREB), including phosphorylation at Ser133 and its nuclear translocation. | Cilostazol | cAMP responsive element binding protein 1 | Homo sapiens |
| 2 | Deletion and mutational analysis of the contractile protein promoters along with chromatin immunoprecipitation using anti-CREB antibody showed that CRE is essential for cilostazol-induced contractile protein expression. | Cilostazol | cAMP responsive element binding protein 1 | Homo sapiens |
| 3 | Transfection of dominant-negative CREB (mutated Ser133) plasmid in VSMCs blocked cilostazol-stimulated contractile protein expression. | Cilostazol | cAMP responsive element binding protein 1 | Homo sapiens |
| 4 | In vivo, cilostazol upregulated contractile proteins and induced the activation of CREB in the neointima of balloon-injured arteries. | Cilostazol | cAMP responsive element binding protein 1 | Homo sapiens |
| 5 | CONCLUSIONS: Cilostazol promotes VSMC differentiation through the cAMP/PKA/CREB signaling cascade. | Cilostazol | cAMP responsive element binding protein 1 | Homo sapiens |