Pub. Date : 2011 Aug
PMID : 21673091
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. | OSI 027 | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Here, we report the preclinical characterization of OSI-027, a selective and potent dual inhibitor of mTORC1 and mTORC2 with biochemical IC(50) values of 22 nmol/L and 65 nmol/L, respectively. | OSI 027 | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | OSI-027 inhibits phosphorylation of the mTORC1 substrates 4E-BP1 and S6K1 as well as the mTORC2 substrate AKT in diverse cancer models in vitro and in vivo. | OSI 027 | CREB regulated transcription coactivator 1 | Mus musculus |