PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21673091-0 2011 Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. OSI 027 32-39 CREB regulated transcription coactivator 1 Mus musculus 77-83 21673091-4 2011 Here, we report the preclinical characterization of OSI-027, a selective and potent dual inhibitor of mTORC1 and mTORC2 with biochemical IC(50) values of 22 nmol/L and 65 nmol/L, respectively. OSI 027 52-59 CREB regulated transcription coactivator 1 Mus musculus 102-108 21673091-6 2011 OSI-027 inhibits phosphorylation of the mTORC1 substrates 4E-BP1 and S6K1 as well as the mTORC2 substrate AKT in diverse cancer models in vitro and in vivo. OSI 027 0-7 CREB regulated transcription coactivator 1 Mus musculus 40-46