Title : Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin.

Pub. Date : 2011 Aug

PMID : 21673091






3 Functional Relationships(s)
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1 Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. OSI 027 CREB regulated transcription coactivator 1 Mus musculus
2 Here, we report the preclinical characterization of OSI-027, a selective and potent dual inhibitor of mTORC1 and mTORC2 with biochemical IC(50) values of 22 nmol/L and 65 nmol/L, respectively. OSI 027 CREB regulated transcription coactivator 1 Mus musculus
3 OSI-027 inhibits phosphorylation of the mTORC1 substrates 4E-BP1 and S6K1 as well as the mTORC2 substrate AKT in diverse cancer models in vitro and in vivo. OSI 027 CREB regulated transcription coactivator 1 Mus musculus