Title : Multiple signalling pathways underlie the protective effect of levosimendan in cardiac myocytes.

Pub. Date : 2011 Sep 30

PMID : 21664904






2 Functional Relationships(s)
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1 Pretreatment with levosimendan reversed the effects of ischaemia and ischaemia/reperfusion on cell viability and enhanced phosphorylation of Akt, p38-mitogen activated protein kinase (MAPK) and extracellular signal-regulated kinases 1/2 (ERK1/2). Simendan mitogen-activated protein kinase 1 Homo sapiens
2 Levosimendan stimulated the phosphorylation of Akt, ERK1/2 and p38-MAPK with different kinetics and the activation of these pathways was dependent on the opening of the mitochondrial K(ATP) channels and the production of oxygen free radicals. Simendan mitogen-activated protein kinase 1 Homo sapiens