Title : Ceramide formation as a target in beta-cell survival and function.

Pub. Date : 2011 Sep

PMID : 21635197






1 Functional Relationships(s)
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1 Ceramide-dependent signaling involves activation of extracellularly regulated kinases 1 and 2 (ERK1/2), downregulation of Period (Per)-aryl hydrocarbon receptor nuclear translocator (Arnt)-single-minded (Sim) kinase (PASK), activation of okadaic-acid-sensitive protein phosphatase 2A (PP2A) and stimulation of NADPH-oxidase with generation of superoxides and lipid peroxides. Ceramides protein phosphatase 2 phosphatase activator Homo sapiens