Title : Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids.

Pub. Date : 2011 Jul-Aug

PMID : 21570480






4 Functional Relationships(s)
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1 RESULTS: PA and IAB fat reduced insulin-stimulated glucose uptake and their combined effect was similar to that of PA alone. Palmitic Acid insulin Homo sapiens
2 PA-induced insulin resistance was ameliorated by inhibiting the de novo synthesis of ceramide, IkappaBalpha degradation or mTOR activation. Palmitic Acid insulin Homo sapiens
3 CONCLUSIONS: PA-induced insulin resistance in skeletal muscle involves inflammatory (nuclear factor kappa B/mTOR) and nutrient (ceramide) pathways. Palmitic Acid insulin Homo sapiens
4 PUFAs promote pathways, at a transcriptional level, that increase fat oxidation and synergize with factors from SC fat to abrogate PA-induced insulin resistance. Palmitic Acid insulin Homo sapiens