Title : Natural plant extract tubeimoside I induces cytotoxicity via the mitochondrial pathway in human normal liver cells.

Pub. Date : 2011 Jul-Aug

PMID : 21537846






1 Functional Relationships(s)
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1 The TBMS I-induced growth inhibition of L-02 cells was accompanied by the collapse of mitochondrial membrane potential, release of cyt-c from the mitochondria to the cytosol, activation of caspase-9 and -3, decrease of anti-apoptotic protein Bcl-2 levels and increase of the pro-apoptotic protein Bax levels, all indicative of apoptosis through the mitochondrial pathway. tubeimoside I BCL2 apoptosis regulator Homo sapiens