Pub. Date : 2011 Jul
PMID : 21327909
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | The objective of this research was to study the effects of SLCO1B1 polymorphisms on the pharmacokinetics and pharmacodynamics of repaglinide in healthy Chinese volunteers. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 3 | CONCLUSIONS: SLCO1B1*1B/*1B genotype is associated with reduced pharmacokinetic exposure after a single dose oral administration of 2 mg repaglinide, including decreased AUC(0- ) and increased clearance of repaglinide. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 4 | CONCLUSIONS: SLCO1B1*1B/*1B genotype is associated with reduced pharmacokinetic exposure after a single dose oral administration of 2 mg repaglinide, including decreased AUC(0- ) and increased clearance of repaglinide. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 5 | Moreover, this polymorphism of SLCO1B1 has significant influence on the pharmacokinetics of repaglinide, but no effects on its pharmacodynamics. | repaglinide | solute carrier organic anion transporter family member 1B1 | Homo sapiens |