Title : FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo.

Pub. Date : 2011 Mar 24

PMID : 21263155






2 Functional Relationships(s)
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1 We examined in vivo FLT3 inhibition in acute myeloid leukemia patients treated with chemotherapy followed by the FLT3 inhibitor lestaurtinib, comparing newly diagnosed acute myeloid leukemia patients with relapsed patients. lestaurtinib fms related receptor tyrosine kinase 3 Homo sapiens
2 Because we noted that in vivo FLT3 inhibition by lestaurtinib was less effective in the relapsed patients compared with the newly diagnosed patients, we investigated whether plasma FLT3 ligand (FL) levels could influence the efficacy of FLT3 inhibition in these patients. lestaurtinib fms related receptor tyrosine kinase 3 Homo sapiens