Pub. Date : 2011 May
PMID : 21236267
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Irbesartan inhibits advanced glycation end product (AGE)-induced up-regulation of vascular cell adhesion molecule-1 (VCAM-1) mRNA levels in glomerular endothelial cells. | Irbesartan | vascular cell adhesion molecule 1 | Homo sapiens |
| 2 | Irbesartan inhibits advanced glycation end product (AGE)-induced up-regulation of vascular cell adhesion molecule-1 (VCAM-1) mRNA levels in glomerular endothelial cells. | Irbesartan | vascular cell adhesion molecule 1 | Homo sapiens |
| 3 | In this study, we examined whether and how irbesartan, an angiotensin II type 1 receptor blocker (ARB), inhibited the AGE-induced vascular cell adhesion molecule-1 (VCAM-1) gene expression in cultured human glomerular ECs. | Irbesartan | vascular cell adhesion molecule 1 | Homo sapiens |
| 4 | In this study, we examined whether and how irbesartan, an angiotensin II type 1 receptor blocker (ARB), inhibited the AGE-induced vascular cell adhesion molecule-1 (VCAM-1) gene expression in cultured human glomerular ECs. | Irbesartan | vascular cell adhesion molecule 1 | Homo sapiens |
| 5 | Irbesartan or an anti-oxidant N-acetylcysteine inhibited the AGE-induced increase in reactive oxygen species (ROS) generation and subsequently blocked up-regulation of VCAM-1 mRNA levels in glomerular ECs. | Irbesartan | vascular cell adhesion molecule 1 | Homo sapiens |
| 6 | Furthermore, irbesartan completely suppressed up-regulation of VCAM-1 mRNA levels in AGE plus angiotensin II-exposed glomerular ECs. | Irbesartan | vascular cell adhesion molecule 1 | Homo sapiens |