Pub. Date : 2011 May
PMID : 21213107
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As the genetically polymorphic cytochrome P450 (CYP), enzyme CYP2C9 is mainly responsible for the hepatic metabolism of sulfonylureas (SUs), we hypothesized that the slow-metabolizer genotypes *2/*2, *2/*3, and *3/*3 might be overrepresented in type 2 diabetic patients with SH. | Sulfonylurea Compounds | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | As the genetically polymorphic cytochrome P450 (CYP), enzyme CYP2C9 is mainly responsible for the hepatic metabolism of sulfonylureas (SUs), we hypothesized that the slow-metabolizer genotypes *2/*2, *2/*3, and *3/*3 might be overrepresented in type 2 diabetic patients with SH. | Sulfonylurea Compounds | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | However, in the control group, patients with CYP2C9 genotypes, predicting slower metabolism of SU drugs, were treated with significantly lower doses (p = 0.027) than were extensive metabolizers, whereas in the patient group with severe hypoglycemia, the dose was the same for all genotype groups. | Sulfonylurea Compounds | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |