PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21213107-2 2011 As the genetically polymorphic cytochrome P450 (CYP), enzyme CYP2C9 is mainly responsible for the hepatic metabolism of sulfonylureas (SUs), we hypothesized that the slow-metabolizer genotypes *2/*2, *2/*3, and *3/*3 might be overrepresented in type 2 diabetic patients with SH. Sulfonylurea Compounds 120-133 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 61-67 21213107-2 2011 As the genetically polymorphic cytochrome P450 (CYP), enzyme CYP2C9 is mainly responsible for the hepatic metabolism of sulfonylureas (SUs), we hypothesized that the slow-metabolizer genotypes *2/*2, *2/*3, and *3/*3 might be overrepresented in type 2 diabetic patients with SH. Sulfonylurea Compounds 135-138 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 61-67 21213107-9 2011 However, in the control group, patients with CYP2C9 genotypes, predicting slower metabolism of SU drugs, were treated with significantly lower doses (p = 0.027) than were extensive metabolizers, whereas in the patient group with severe hypoglycemia, the dose was the same for all genotype groups. Sulfonylurea Compounds 95-97 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 45-51