Title : [Medication of the month. Sitagliptin-metformin fixed combination (Janumet)].

Pub. Date : 2010 Nov

PMID : 21189532






1 Functional Relationships(s)
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1 Janumet is a fixed-dose combination of sitagliptin, a specific inhibitor of dipeptidylpeptidase-4 that blocks the rapid degradation of so-called incretin hormones (resulting in a potentiation of insulin secretion and reduction of glucagon secretion in a glucose-dependent manner), and of metformin, a biguanide compound that reduces glucose hepatic production and slightly improves insulin sensitivity. Sitagliptin Phosphate insulin Homo sapiens