PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21189532-4 2010 Janumet is a fixed-dose combination of sitagliptin, a specific inhibitor of dipeptidylpeptidase-4 that blocks the rapid degradation of so-called incretin hormones (resulting in a potentiation of insulin secretion and reduction of glucagon secretion in a glucose-dependent manner), and of metformin, a biguanide compound that reduces glucose hepatic production and slightly improves insulin sensitivity. Sitagliptin Phosphate 39-50 insulin Homo sapiens 195-202