Pub. Date : 2011 Apr
PMID : 21133803
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Since the AIF versus MYF phenotype is determined by the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and Wingless/Int (Wnt) signaling, respectively, the authors hypothesized that nicotine-induced AIF-to-MYF transdifferentiation is characterized by the down-regulation of PPARgamma, and the up-regulation of the Wnt signaling pathway. | Nicotine | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 2 | Since the AIF versus MYF phenotype is determined by the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and Wingless/Int (Wnt) signaling, respectively, the authors hypothesized that nicotine-induced AIF-to-MYF transdifferentiation is characterized by the down-regulation of PPARgamma, and the up-regulation of the Wnt signaling pathway. | Nicotine | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 3 | Since the AIF versus MYF phenotype is determined by the expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and Wingless/Int (Wnt) signaling, respectively, the authors hypothesized that nicotine-induced AIF-to-MYF transdifferentiation is characterized by the down-regulation of PPARgamma, and the up-regulation of the Wnt signaling pathway. | Nicotine | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 4 | Furthermore, activation of nicotinic acetylcholine receptor (nAChR)-alpha3 and -alpha7 and whether a PPARgamma agonist, rosiglitazone (RGZ), blocks nicotine-mediated Wnt activation were examined. | Nicotine | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 5 | Nicotine-mediated Wnt activation was almost completely blocked by pretreatment with either calphostin C or RGZ, indicating the central involvement of PKC activation and Wnt/PPARgamma interaction in nicotine-induced up-regulation of Wnt signaling, and hence AIF-to-MYF transdifferentiation, providing novel preventive/therapeutic targets for nicotine-induced lung injury. | Nicotine | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 6 | Nicotine-mediated Wnt activation was almost completely blocked by pretreatment with either calphostin C or RGZ, indicating the central involvement of PKC activation and Wnt/PPARgamma interaction in nicotine-induced up-regulation of Wnt signaling, and hence AIF-to-MYF transdifferentiation, providing novel preventive/therapeutic targets for nicotine-induced lung injury. | Nicotine | peroxisome proliferator activated receptor gamma | Homo sapiens |
| 7 | Nicotine-mediated Wnt activation was almost completely blocked by pretreatment with either calphostin C or RGZ, indicating the central involvement of PKC activation and Wnt/PPARgamma interaction in nicotine-induced up-regulation of Wnt signaling, and hence AIF-to-MYF transdifferentiation, providing novel preventive/therapeutic targets for nicotine-induced lung injury. | Nicotine | peroxisome proliferator activated receptor gamma | Homo sapiens |