Protein Name | peroxisome proliferator activated receptor gamma |
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Organism | Homo sapiens |
Gene ID | 5468 |
Gene Symbol | PPARG |
UniProt | P37231 (PPARG_HUMAN), D2KUA6 (D2KUA6_HUMAN), E9PFX5 (E9PFX5_HUMAN), A0A494C1F9 (A0A494C1F9_HUMAN), E9PFV2 (E9PFV2_HUMAN) |
Relationships |
Total Number of functionally related compound(s) :
2156
Total Number of Articles : 5794 |
Description |
peroxisome proliferator activated receptor gamma |
Gene Summary |
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008] |
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