Protein Name peroxisome proliferator activated receptor gamma
Organism Homo sapiens
Gene ID 5468
Gene Symbol

PPARG

UniProt P37231 (PPARG_HUMAN), D2KUA6 (D2KUA6_HUMAN), E9PFX5 (E9PFX5_HUMAN), A0A494C1F9 (A0A494C1F9_HUMAN), E9PFV2 (E9PFV2_HUMAN)
Relationships Total Number of functionally related compound(s) : 2156
Total Number of Articles : 5794
Description

peroxisome proliferator activated receptor gamma

Gene Summary

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

synonyms
  • peroxisome proliferator-activated receptor gamma
  • PPAR-gamma
  • nuclear receptor subfamily 1 group C member 3
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Properties