Title : Multimer size dependence of von Willebrand factor binding to crosslinked or noncrosslinked fibrin.

Pub. Date : 1990 Apr 1

PMID : 2107883






3 Functional Relationships(s)
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1 Culture medium containing constitutively secreted vWF was removed from metabolically labeled primary cultures of human umbilical vein EC, and vWF released from WPB was obtained after stimulation by A23187. Calcimycin von Willebrand factor Homo sapiens
2 Multimers of greater than 20 subunits represented 60% +/- 4% (SEM) of A23187 released vWF and 11% +/- 5% of media vWF, but binding to fibrin was similar, 96% +/- 1% and 94% +/- 2%, respectively. Calcimycin von Willebrand factor Homo sapiens
3 A progressively smaller proportion of vWF bound as multimer size decreased, and dimeric vWF binding was least, with 34% +/- 5% binding from A23187 releasate and 51% +/- 4% from media. Calcimycin von Willebrand factor Homo sapiens