Title : Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration.

Pub. Date : 2010 Oct

PMID : 21040239






3 Functional Relationships(s)
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1 Noribogaine, but not 18-MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self-administration. noribogaine glial cell derived neurotrophic factor Homo sapiens
2 Here, we determined whether noribogaine and/or 18-MC, like ibogaine, increase GDNF expression, and whether their site of action to reduce alcohol consumption is the VTA. noribogaine glial cell derived neurotrophic factor Homo sapiens
3 We used SH-SY5Y cells as a cell culture model and found that noribogaine, like ibogaine, but not 18-MC, induces a robust increase in GDNF mRNA levels. noribogaine glial cell derived neurotrophic factor Homo sapiens