Pub. Date : 2010 Dec
PMID : 20964620
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of CYP3A-mediated testosterone 6beta-hydroxylation by tanshinone IIA and midazolam 1-hydroxylation by cryptotanshinone in human liver microsomes. | tanshinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | This study evaluated the in vitro activation of CYP3A-mediated midazolam 1-hydroxylation and testosterone 6beta-hydroxylation by tanshinone I, tanshinone IIA, and cryptotanshinone. | tanshinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | This study evaluated the in vitro activation of CYP3A-mediated midazolam 1-hydroxylation and testosterone 6beta-hydroxylation by tanshinone I, tanshinone IIA, and cryptotanshinone. | tanshinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The abilities of tanshinones to activate CYP3A-mediated midazolam 1-hydroxylation and testosterone 6beta-hydroxylation in human liver microsomes (HLMs) were tested. | tanshinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Substrate- and effector-dependent activation of CYP3A by tanshinones were both observed. | tanshinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | In addition, tanshinone IIA activated CYP3A-mediated testosterone 6beta-hydroxylation, whereas cryptotanshinone and tanshinone I did not. | tanshinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 7 | In addition, tanshinone IIA activated CYP3A-mediated testosterone 6beta-hydroxylation, whereas cryptotanshinone and tanshinone I did not. | tanshinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 8 | The results from our study enhance the understanding of CYP3A activation by tanshinone IIA and cryptotanshinone in HLMs. | tanshinone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |