Title : An investigation of reversal of imatinib resistance in the Bcr-Abl positive imatinib-resistant cell line K562r by dasatinib, nilotinib, rapamycin and bortezomib.

Pub. Date : 2011 Apr

PMID : 20942869






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1 An investigation of reversal of imatinib resistance in the Bcr-Abl positive imatinib-resistant cell line K562r by dasatinib, nilotinib, rapamycin and bortezomib. nilotinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 CONCLUSION: K562r due to duplication of autophosphorylation of wild-type Bcr-Abl induced by imatinib was still partially resistant to dasatinib and nilotinib, but this was overcome by incremental dosing. nilotinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens