PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20921456-1 2010 PURPOSE: To evaluate the safety, maximum-tolerated dose, pharmacokinetics, and pharmacodynamics of vandetanib, an oral vascular endothelial growth factor receptor 2 (VEGFR2) and epidermal growth factor receptor inhibitor, administered once daily during and after radiotherapy in children with newly diagnosed diffuse intrinsic pontine glioma. vandetanib 99-109 kinase insert domain receptor Homo sapiens 119-164