Pub. Date : 2011 Dec
PMID : 20607587
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modulation of P-gp expression by lapatinib. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | We examined the impact of co-incubation of chemotherapy drugs in combination with lapatinib in P-gp over-expressing drug resistant cells. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Unexpectedly, lapatinib treatment, at clinically relevant concentrations, increased levels of the P-gp drug transporter in a dose- and time-responsive manner. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Despite the lapatinib-induced alteration in P-gp expression, use of accumulation, efflux and toxicity assays demonstrated that the induced alteration in P-gp expression by lapatinib had little direct impact on drug resistance. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Despite the lapatinib-induced alteration in P-gp expression, use of accumulation, efflux and toxicity assays demonstrated that the induced alteration in P-gp expression by lapatinib had little direct impact on drug resistance. | Lapatinib | ATP binding cassette subfamily B member 1 | Homo sapiens |