Pub. Date : 2010 Aug
PMID : 20592724
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast. | montelukast | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
2 | Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast. | montelukast | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
3 | In order to study the significance of CYP2C8 in the pharmacokinetics of montelukast, 10 healthy subjects were administered gemfibrozil 600 mg or placebo twice daily for 3 days, and 10 mg montelukast on day 3, in a randomized, crossover study. | montelukast | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
4 | In conclusion, gemfibrozil markedly increases the plasma concentrations of montelukast, indicating that CYP2C8 is crucial in the elimination of montelukast. | montelukast | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |
5 | In conclusion, gemfibrozil markedly increases the plasma concentrations of montelukast, indicating that CYP2C8 is crucial in the elimination of montelukast. | montelukast | cytochrome P450 family 2 subfamily C member 8 | Homo sapiens |