Title : Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast.

Pub. Date : 2010 Aug

PMID : 20592724






5 Functional Relationships(s)
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1 Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast. montelukast cytochrome P450 family 2 subfamily C member 8 Homo sapiens
2 Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast. montelukast cytochrome P450 family 2 subfamily C member 8 Homo sapiens
3 In order to study the significance of CYP2C8 in the pharmacokinetics of montelukast, 10 healthy subjects were administered gemfibrozil 600 mg or placebo twice daily for 3 days, and 10 mg montelukast on day 3, in a randomized, crossover study. montelukast cytochrome P450 family 2 subfamily C member 8 Homo sapiens
4 In conclusion, gemfibrozil markedly increases the plasma concentrations of montelukast, indicating that CYP2C8 is crucial in the elimination of montelukast. montelukast cytochrome P450 family 2 subfamily C member 8 Homo sapiens
5 In conclusion, gemfibrozil markedly increases the plasma concentrations of montelukast, indicating that CYP2C8 is crucial in the elimination of montelukast. montelukast cytochrome P450 family 2 subfamily C member 8 Homo sapiens