PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20592724-0 2010 Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast. montelukast 60-71 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 108-114 20592724-0 2010 Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast. montelukast 136-147 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 108-114 20592724-2 2010 In order to study the significance of CYP2C8 in the pharmacokinetics of montelukast, 10 healthy subjects were administered gemfibrozil 600 mg or placebo twice daily for 3 days, and 10 mg montelukast on day 3, in a randomized, crossover study. montelukast 72-83 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 38-44 20592724-6 2010 In conclusion, gemfibrozil markedly increases the plasma concentrations of montelukast, indicating that CYP2C8 is crucial in the elimination of montelukast. montelukast 75-86 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 104-110 20592724-6 2010 In conclusion, gemfibrozil markedly increases the plasma concentrations of montelukast, indicating that CYP2C8 is crucial in the elimination of montelukast. montelukast 144-155 cytochrome P450 family 2 subfamily C member 8 Homo sapiens 104-110