Title : Celecoxib increases retinoid sensitivity in human colon cancer cell lines.

Pub. Date : 2010 Sep

PMID : 20496179






2 Functional Relationships(s)
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1 Western blotting showed that the expression of RARbeta in HT-29 cell lines was increased by celecoxib, but not by NS398, and that the addition of PGE(2) did not affect the celecoxib-induced expression of the retinoic acid receptor beta. Celecoxib retinoic acid receptor beta Homo sapiens
2 In conclusion, celecoxib increased the expression of RARbeta and the level of cellular ATRA sensitivity through COX-2-independent mechanisms. Celecoxib retinoic acid receptor beta Homo sapiens