Title : Prostacyclin receptor suppresses cardiac fibrosis: role of CREB phosphorylation.

Pub. Date : 2010 Aug

PMID : 20403362






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 This effect of cicaprost was unlikely to be mediated by inhibition of the Smad2/3 or mitogen-activated protein kinase (MAPK) activities, but was associated with cAMP elevation and phosphorylation of the transcription factor cAMP response element binding protein (CREB). cicaprost cAMP responsive element binding protein 1 Mus musculus
2 This effect of cicaprost was unlikely to be mediated by inhibition of the Smad2/3 or mitogen-activated protein kinase (MAPK) activities, but was associated with cAMP elevation and phosphorylation of the transcription factor cAMP response element binding protein (CREB). cicaprost cAMP responsive element binding protein 1 Mus musculus
3 Expression of a non-phosphorylated CREB mutant suppressed the inhibitory effect of cicaprost. cicaprost cAMP responsive element binding protein 1 Mus musculus