Title : The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes.

Pub. Date : 2010 Apr 9

PMID : 20230793






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1 The citrus flavonoids hesperetin and naringenin block the lipolytic actions of TNF-alpha in mouse adipocytes. naringenin tumor necrosis factor Mus musculus
2 In this report, we show that hesperetin and naringenin, two citrus flavonoids, inhibit TNF-alpha-stimulated FFA secretion from mouse adipocytes. naringenin tumor necrosis factor Mus musculus
3 Moreover, hesperetin and naringenin prevent TNF-alpha from downregulating the transcription of two antilipolytic genes, perilipin and PDE3B. naringenin tumor necrosis factor Mus musculus
4 Our results provide novel evidence that hesperetin and naringenin directly inhibit TNF-alpha-stimulated FFA secretion. naringenin tumor necrosis factor Mus musculus