Title : Src-dependent TrkA transactivation is required for pituitary adenylate cyclase-activating polypeptide 38-mediated Rit activation and neuronal differentiation.

Pub. Date : 2010 May 1

PMID : 20219970






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PACAP receptor (PACR1) stimulation triggered both G(i)alpha and G(s)alpha/cAMP/Epac regulatory cascades resulting in Src kinase activity, which in turn induced TrkA kinase tyrosine phosphorylation. Tyrosine adenylate cyclase activating polypeptide 1 Homo sapiens
2 A single tyrosine (Y(499)) phosphorylation event was identified as critical to both PACAP-mediated transactivation and TrkA-dependent Rit activation. Tyrosine adenylate cyclase activating polypeptide 1 Homo sapiens