Title : Cardiac gap junction channels are upregulated by metoprolol: an unexpected effect of beta-blockers.

Pub. Date : 2010

PMID : 20215810






3 Functional Relationships(s)
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1 CONCLUSION: Both isomers of metoprolol upregulate connexin-43 in cultured cardiomyocytes by a beta-adrenoceptor-independent mechanism. Metoprolol gap junction protein, alpha 1 Rattus norvegicus
2 Since the enhanced presence of connexin-43 in cell membranes under metoprolol was not accompanied by enhanced connexin-43 mRNA, we assume that the metoprolol effect involves reduced connexin-43 degradation. Metoprolol gap junction protein, alpha 1 Rattus norvegicus
3 Since the enhanced presence of connexin-43 in cell membranes under metoprolol was not accompanied by enhanced connexin-43 mRNA, we assume that the metoprolol effect involves reduced connexin-43 degradation. Metoprolol gap junction protein, alpha 1 Rattus norvegicus