| Protein Name | gap junction protein, alpha 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24392 |
| Gene Symbol | Gja1 |
| UniProt | P08050 (CXA1_RAT), A0A654ICE6 (A0A654ICE6_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
574
Total Number of Articles : 760 |
Description |
gap junction protein, alpha 1 |
| Gene Summary |
Enables connexin binding activity; gap junction channel activity; and protein domain specific binding activity. Involved in several processes, including blood vessel diameter maintenance; negative regulation of cell population proliferation; and reproductive structure development. Located in several cellular components, including endosome; fascia adherens; and gap junction. Part of connexin complex. Used to study Parkinsonism; amnestic disorder; high grade glioma; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); autoimmune thyroiditis; borna disease; ischemia (multiple); and tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive craniometaphyseal dysplasia; congenital heart disease (multiple); erythrokeratodermia variabilis (multiple); oculodentodigital dysplasia; and palmoplantar keratoderma and congenital alopecia 1. Orthologous to human GJA1 (gap junction protein alpha 1). [provided by Alliance of Genome Resources, Apr 2022] |
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